ABSTRACT
Objective/background: The objective/background of this work was to study the efficacy and safety of quercetin and polyvinylpyrrolidone [QP] in the treatment of patients with newly diagnosed destructive pulmonary tuberculosis in comparison with standard antimycobacterial therapy
Materials and methods: The study involved 124 patients aged between 20 years and 70 years with newly diagnosed destructive pulmonary tuberculosis. Patients were allocated to two groups. The first [control] group of patients received standard antimycobacterial and pathogenetic therapy and included 31 [25.00 +/- 3.89%] patients. The second [main] group of patients received QP therapy in addition to chemotherapy and included 93 [75.00 +/- 3.89%] patients
Results: Intoxication symptoms in the second group were reduced following 1.33 +/- 0.15 months, whereas in the first group intoxication symptoms were reduced following 2.64 +/- 0.20 months, p < .001
Conclusion: Administration of QP combined with chemotherapy in patients with newly diagnosed destructive pulmonary tuberculosis resulted in a comparatively quick reduction of disease manifestation